Ongoing progress in research on drug exposure and adverse events

Adverse drug events in the elderly: an ongoing problem.

formal continuing medical education (CME) programs, pocket cards listing high-risk medications, messaging in the electronic medical record suggesting therapeutic alternatives to high-risk medications, focused therapeutic interchange initiatives, and dissemination of “frequently asked questions” documents. These tools are designed to explain, teach, and reinforce the message that many drugs adve...

The Research on Adverse Drug Events and Reports

Contact me when new articles are published in these topic areas. A DVERSE DRUG AND DEVICE REactions (ADRs) account for as many as 100 000 deaths annually. 1 Prior to US Food and Drug Administration (FDA) approval, drugs are evaluated in well-designed and carefully monitored clinical trials. Only half of newly discovered serious ADRs are detected and documented in the Phy-sicians' Desk Reference...

Anticoagulation-associated adverse drug events.

PURPOSE Anticoagulant drugs are among the most common medications that cause adverse drug events (ADEs) in hospitalized patients. We performed a 5-year retrospective study at Brigham and Women's Hospital to determine clinical characteristics, types, root causes, and outcomes of anticoagulant-associated ADEs. METHODS We reviewed all inpatient anticoagulant-associated ADEs, including adverse dr...

Minimizing adverse drug events in older patients.

Adverse drug events are common in older patients, particularly in those taking at least five medications, but such events are predictable and often preventable. A rational approach to prescribing in older adults integrates physiologic changes of aging with knowledge of pharmacology. Focusing on specific outcomes, such as the prompt recognition of adverse drug events, allows the family physician...

HIV-related TB and adverse drug events.